The following study is a systematic review and meta-analysis assessing the efficacy of antidepressants in children and adolescents with major depressive disorder. This study used two independent reviewers to search for eligible studies. Ultimately, 17 randomized control trials and 2, 537 participants. The antidepressants studied included tricyclic antidepressants, SSRI’s, and SNRI’s. Functioning at school, at home, and with peers were evaluated. Quality of life was also assessed by administering a questionnaire evaluating a patient’s views on health, wellbeing, and feelings of life. The study concluded that antidepressants were effective in improving function but not quality of life in pediatric patients. Although these findings suggest that antidepressants do have a positive impact on pediatric patients with major depressive disorder, this study also shows that they are not the definitive treatment option for MDD. Other factors such as support, safety, diet, and exercise must be considered to cultivate the best environment for a patient to succeed. To delve further in area of study, I would search for studies tat specifically looked at one type of antidepressant, such as SSRI’s, in conjunction with lifestyle changes to see if these methods are effective in treating MDD for a longer-term period in pediatric patients.